机构：[1]Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.[2]Anhui Medical University, Anhui 230031, China.[3]Yunnan Provincial Hospital of Infectious Disease, AIDS Care Center (YNACC), Kunming 650000, China.
Since the first identification of HIV-1 outbreak in Dehong, Yunnan province has been the epidemic center of HIV in China. Owing to the special geographic location and the frequent population mobility, Yunnan province contained complex HIV subtype distribution. Many new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) have been found in recent years. In this study, a unique HIV-1 recombinant strain genome (YN10134) was characterized from an HIV-positive female in Yunnan, China. This virus genome had a complex intersubtype recombinant structure with eight breakpoints, composed of subtypes B and C. Although the sequence had a similar breakpoint with CRF07_BC in the start position in Env, the phylogenetic analysis showed that the segment was not originated from CRF07_BC. The identification of the URF indicated the severity of the HIV epidemic in Yunnan province and the urgent need for epidemiological surveillance of the new recombination.
基金：
National Natural Science Foundation of China
(No. 81273137).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区免疫学4 区传染病学4 区病毒学
最新[2023]版：
大类|4 区医学
小类|4 区免疫学4 区传染病学4 区病毒学
第一作者：
第一作者机构：[1]Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.[*1]Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology 20 Dongda Street, Fengtai District, Beijing, 100071, China.
推荐引用方式(GB/T 7714)：
Wang Xiaolin,Zhang Min,Li Jianjian,et al.Genetic Characterization of a Unique Recombinant Strain Identified in Yunnan with Genome Comprising B and C[J].AIDS research and human retroviruses.2017,33(6):614-620.doi:10.1089/AID.2017.0013.
APA：
Wang Xiaolin,Zhang Min,Li Jianjian,Li Tianyi,Sun Changrong...&Li Lin.(2017).Genetic Characterization of a Unique Recombinant Strain Identified in Yunnan with Genome Comprising B and C.AIDS research and human retroviruses,33,(6)
MLA：
Wang Xiaolin,et al."Genetic Characterization of a Unique Recombinant Strain Identified in Yunnan with Genome Comprising B and C".AIDS research and human retroviruses 33..6(2017):614-620
