机构：[1]Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China[2]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China[3]Yunnan Provincial Center for Disease Control and Prevention, Kunming, China[4]Henan Provincial Centers for Disease Control and Prevention, Zhengzhou, China[5]Sexually Transmitted Disease and AIDS Department, Shandong Provincial Center for Disease Control and Prevention, Jinan, China[6]AIDS/STIs Prevention and Control Department, Hunan Provincial Center for Disease Control and Prevention, Changsha, China[7]Sexually Transmitted Disease and AIDS Prevention and Control Department, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China[8]Sexually Transmitted Disease and AIDS Department, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China[9]Rhode Island Hospital, Providence, RI.
To elucidate new features in the prevalence of HIV-1 transmitted drug resistance (TDR) in men who have sex with men (MSM) in China.
A total of 441 HIV-1-positive subjects were recruited from high-risk MSM populations in 7 cities across China between 2012 and 2013. Nucleotide sequences of 1.1-kb pol-RT regions were amplified and sequenced from 367 of the 441 samples. Phylogenetic and genetic drug-resistant analyses were performed.
The overall distribution of HIV-1 genotypes was as the following: CRF01_AE, 52.3%; CRF07_BC, 33.2%; 01/B recombinants, 6.0%; subtype B (United States-European), 3.8%; subtype B', 3.8%; and CRF08_BC, 0.8%. About 91.3% of the sequences clustered together. An overall 4.6% TDR rate was found. Reverse transcriptase (RT)-related TDR reached 2.7%. TDR of 2.2% was detected in protease region. Most of RT-related TDRs were detected in non-CRF01_AE subtypes (90.0%, 9/10), including T215A/S, K101E, K103N, V106M, and E138G. Most of the strains with TDRs (88.2%, 15/17) were presented in the clusters. TDR strains against non-nucleoside reverse transcriptase inhibitors in non-CRF01_AE subtypes also formed some subclusters (70.0%, 7/10). One CRF07_BC subject with K103N in Kunming had a very close genetic distance with one that received highly active antiretroviral therapy locally (bootstrap = 99%). Two CRF55_01B subjects carrying K103N in Changsha and Nanjing also had a very close genetic distance (bootstrap = 100%).
RT-related TDR of non-CRF01_AE became the main TDR among MSM in China. There is an increasing trend and a potential transmission risk for the RT-related TDR among MSM throughout China. Some TDRs could have already been transmitted among different cities. Intervention efforts should be strengthened among MSM to prevent further transmission of HIV and the proliferation of the strains with TDR.
基金：
National Natural Science
(81371787), Fund of National Natural Science (81001316), and Fund
of National Natural Science (81102231) in China
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|2 区医学
小类|2 区免疫学2 区传染病学
最新[2023]版：
大类|3 区医学
小类|3 区免疫学3 区传染病学
第一作者：
第一作者机构：[1]Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China[2]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
通讯作者：
通讯机构：[1]Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China[2]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China[*1]Key Laboratory of AIDS Immunology National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
推荐引用方式(GB/T 7714)：
Zhao Bin,Han Xiaoxu,Xu Junjie,et al.Increase of RT-related transmitted drug resistance in non-CRF01_AE among HIV type 1-infected men who have sex with men in the 7 cities of China.[J].Journal of acquired immune deficiency syndromes (1999).2015,68(3):250-5.doi:10.1097/QAI.0000000000000467.
APA：
Zhao Bin,Han Xiaoxu,Xu Junjie,Hu Qinghai,Chu Zhenxing...&Shang Hong.(2015).Increase of RT-related transmitted drug resistance in non-CRF01_AE among HIV type 1-infected men who have sex with men in the 7 cities of China..Journal of acquired immune deficiency syndromes (1999),68,(3)
MLA：
Zhao Bin,et al."Increase of RT-related transmitted drug resistance in non-CRF01_AE among HIV type 1-infected men who have sex with men in the 7 cities of China.".Journal of acquired immune deficiency syndromes (1999) 68..3(2015):250-5
