机构：[1]Department of Anorectal Surgery, The First People’s Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming University of Science and Technology, Kunming, Yunnan, China,云南省第一人民医院[2]Department of General Surgery, The First People’s Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming University of Science and Technology, Kunming, Yunnan, China,云南省第一人民医院[3]Department of Operating Room, The First People’s Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming University of Science and Technology, Kunming, Yunnan, China,外科片麻醉手术科云南省第一人民医院[4]Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China,[5]Department of Dermatology, BenQ Medical Center, Nanjing Medical University, Nanjing, Jiangsu, China,[6]Department of General Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China昆明医科大学附属第一医院
In the present study, we examined the mechanisms of oxaliplatin-induced drug resistance in human colorectal cancer cell lines HT29 and HCT116. Our results demonstrate a significant autophagy expression in CRC cells after an oxaliplatin treatment. Administration of oxaliplatin to human CRC cells significantly enhanced the expression of HMGB1, which regulated the autophagy response and negatively regulate the cell apoptosis. Moreover, a decreased oxaliplatin -induced autophagy response and an increased apoptosis level were detected in stable CRC cells harboring HMGB1 shRNA. Then we noted that HMGB1 significantly induced extracellular signal-regulated kinase (ERK)/Extracellular signal-regulated kinase kinase (MEK) phosphorylation. Taken together, these data suggest that HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway.
基金：
This research was supported by grants from the National Natural
Science Foundation of China (30860257, 81101188 and
810701297), and Yunnan Provincial Department of Education
(Number: ZD2011007).
第一作者机构：[1]Department of Anorectal Surgery, The First People’s Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming University of Science and Technology, Kunming, Yunnan, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Anorectal Surgery, The First People’s Hospital of Yunnan Province, Kunhua Hospital Affiliated to Kunming University of Science and Technology, Kunming, Yunnan, China,[6]Department of General Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
推荐引用方式(GB/T 7714)：
Weijun Liu,Zhenyong Zhang,Yongxue Zhang,et al.HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway[J].CANCER BIOLOGY & THERAPY.2015,16(4):511-517.doi:10.1080/15384047.2015.1017691.
APA：
Weijun Liu,Zhenyong Zhang,Yongxue Zhang,Xinju Chen,Shikui Guo...&Kunhua Wang.(2015).HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway.CANCER BIOLOGY & THERAPY,16,(4)
MLA：
Weijun Liu,et al."HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway".CANCER BIOLOGY & THERAPY 16..4(2015):511-517
