机构：[1]Department of Thoracic Surgery, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China外科片胸外科云南省第一人民医院[2]Department of Thoracic Surgery, The Affiliated Hospital of Kunming University of Science & Technology, Kunming, Yunnan, China
Aim: To investigate the clinicopathological factors affecting the mSHOX2/mPTGER4 assay performance and its application in lung cancer detection in Chinese population. Materials & methods: A total of 455 subjects were recruited in this case-control study (302 untreated lung cancer patients, 153 normal subjects). Blood samples were collected before therapy and the mSHOX2/mPTGER4 level was measured with Epi proLung assay. Results: The mSHOX2/mPTGER4 sensitivity was 75.6% at 84.8% specificity. Both markers showed stage-dependent sensitivity. mSHOX2 was more sensitive to small-cell lung cancer and mPTGER4 was more sensitive to poorly differentiated lung cancer. Sensitivity increased with age but was not affected by sex. The mPRGER4/mSHOX2 sensitivity was significantly higher than that of protein markers. Conclusion: The mSHOX2/mPTGER4 assay showed some values with more limitations in lung cancer early detection.
基金：
Joint Foundation Science & Technology Department of Yunnan Province and Kunming Medical University. Grant/award number:
grant no. 2017FE468(−246); The Foundation from health commission of Yunnan province. Grant/award number: 2018NS0271.
第一作者机构：[1]Department of Thoracic Surgery, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China[2]Department of Thoracic Surgery, The Affiliated Hospital of Kunming University of Science & Technology, Kunming, Yunnan, China
通讯作者：
通讯机构：[1]Department of Thoracic Surgery, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China[2]Department of Thoracic Surgery, The Affiliated Hospital of Kunming University of Science & Technology, Kunming, Yunnan, China
推荐引用方式(GB/T 7714)：
Xu Zheyuan,Wang Yang,Wang Lan,et al.The performance of the SHOX2/PTGER4 methylation assay is influenced by cancer stage, age, type and differentiation[J].BIOMARKERS IN MEDICINE.2020,14(5):341-351.doi:10.2217/bmm-2019-0325.
APA：
Xu, Zheyuan,Wang, Yang,Wang, Lan,Xiong, Jian,Wang, Han...&Peng, Hao.(2020).The performance of the SHOX2/PTGER4 methylation assay is influenced by cancer stage, age, type and differentiation.BIOMARKERS IN MEDICINE,14,(5)
MLA：
Xu, Zheyuan,et al."The performance of the SHOX2/PTGER4 methylation assay is influenced by cancer stage, age, type and differentiation".BIOMARKERS IN MEDICINE 14..5(2020):341-351
