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Completely genomic and evolutionary characteristics of human-dominant G9P[8] group A rotavirus strains in Yunnan, China

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收录情况： ◇ SCIE

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机构： [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Yunnan 650500, PR China [2]Department of Clinical Laboratory, The First People’s Hospital of Yunnan Province, Yunnan 650032, PR China [3]Department of Clinical Laboratory, Kunming Children’s Hospital, Yunnan 650034, PR China

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关键词： rotavirus acute gastroenteritis genome constellation evolution

摘要：

G9P[8] rotavirus A (RVA) has been identified as the predominant genotype circulating in Yunnan, China. To elucidate the molecular characteristics of its genetic composition at the whole-genome level, the genomes of 12 strains isolated from paediatric patients with diarrhoea were fully sequenced and characterized. Eleven of the 12 strains were genotyped as G9-P [8]-11-R1-C1-M1-Al-N1-T1-E1-H1, which is closely related to the Wa-like genotype 1 constellation. In contrast, one strain was genotyped as G9-P[8]-I1-R1-Cl-M1-Al-N2-T1-El-H1, with the NSP2 gene characterized as a DS-1 like genotype. Bayesian phylogenetic analysis indicated that G9 strains had emerged in 1932 with an estimated average evolutionary rate of 1.63x10(-3) substitutions/site/year. Considering the high prevalence and fast evolutionary rate of G9P[8] rotaviruses, our results suggest that G9P[8] RVA should be strictly monitored in China.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区生物工程与应用微生物 3 区病毒学

最新[2023]版：

大类 | 4 区医学

小类 | 3 区生物工程与应用微生物 4 区病毒学

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出版当年[2016]版：

Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 VIROLOGY

最新[2023]版：

Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 VIROLOGY

影响因子： 3.6 最新[2023版] 3.6 最新五年平均 2.838 出版当年[2016版] 2.902 出版当年五年平均 3.192 出版前一年[2015版] 2.514 出版后一年[2017版]

第一作者：

第一作者机构： [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Yunnan 650500, PR China [2]Department of Clinical Laboratory, The First People’s Hospital of Yunnan Province, Yunnan 650032, PR China

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