详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

Evaluation of portable colposcopy and human papillomavirus testing for screening of cervical cancer in rural China(Open Access)

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester, Massachusetts, USA [2]Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA [3]Kunming University of Science and Technology, Kunming, China [4]Department of Obstetrics and Gynecology, National Health Commission’s Key Laboratory for Healthy Births in Western China, First People's Hospital of Yunnan Province, Yunnan, China [5]Maine Medical Partners Women’s Health Division of Gynecologic Oncology, Portland, Maine, USA [6]Maternal and Child Health and Family Planning Service Center of Longyang District, Yunnan, China [7]Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

出处：

DOI：

ISSN：

关键词： cervical cancer screening human papillomavirus portable colposcopy

摘要：

Objective To evaluate the use of a portable, rechargeable colposcope combined with human papillomavirus (HPV) testing, as compared with HPV testing alone, for screening of cervical cancer and pre-cancerous lesions. Methods This was a cross-sectional study among 488 women in Baoshan County, Yunnan. The women underwent HPV testing followed by Gynocular portable colposcopy with visual inspection with acetic acid. Obvious lesions were biopsied. If portable colposcopy testing was negative but HPV testing was positive, the women underwent follow-up testing with thin-prep cytology and traditional colposcopy. Cervical biopsies were performed for any abnormalities. Histopathology was followed up with diagnosis and treatment. Results Among 488 women screened with portable colposcopy, 24 women underwent biopsy based on positive colposcopy screening. Of these 24 women, three were HPV positive and 21 were HPV negative. Five women had cervical intra-epithelial neoplasia (CIN) I and one had advanced cervical cancer. Forty-six women tested positive for HPV. Three of these women had screened positive on preliminary colposcopy, with one positive for CIN III/squamous cell carcinoma and one woman with CIN I. Forty-three women underwent follow-up testing with thin-prep cytology. Two women had atypical squamous cells of undetermined significance and five had low-grade squamous intra-epithelial lesions and were biopsied; three women had CIN I, one had CIN II and one had CIN III. HPV testing and portable colposcopy was more sensitive but slightly less specific than portable colposcopy or HPV testing alone. Conclusion While HPV testing has high sensitivity and specificity for the detection of pre-cancerous and cancerous lesions and portable colposcopy has lower specificity, both methods of detection have low positive predictive value and high negative predictive value. In tandem, HPV testing and portable colposcopy had higher sensitivity for detection among women who underwent biopsies. In clinical practice, portable colposcopy was an effective, easy and affordable tool to transport to villages where cytology is not currently feasible. © 2019 IGCS and ESGO.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2019]版：

大类 | 4 区医学

小类 | 3 区妇产科学 4 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区妇产科学 3 区肿瘤学

第一作者：

第一作者机构： [1]Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester, Massachusetts, USA [2]Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

共同第一作者：

通讯作者：

通讯机构： [3]Kunming University of Science and Technology, Kunming, China [4]Department of Obstetrics and Gynecology, National Health Commission’s Key Laboratory for Healthy Births in Western China, First People's Hospital of Yunnan Province, Yunnan, China [*1]Department of Obstetricsand Gynecology, National Health Commission’s Key Laboratory for Healthy Births in WesternChina, First People's Hospital of Yunnan Province, Yunnan 650032, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

Evaluation of portable colposcopy and human papillomavirus testing for screening of cervical cancer in rural China(Open Access)

文献详情

相关文献