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云南汉族原发性高血压与HLA-DRB1等位基因的相关性

Alleles of HLA class II DRB1 of patients with essential hypertension in Yunnan Hans

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收录情况： ◇ 中华系列

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机构： [1]昆明市第一人民医院昆明市临床疾病分子生物学重点实验室

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关键词： Alleles Association Human leukocyte antigens Hypertension

摘要：

Objective: To investigate the association between the alleles of human leukocyte antigens (HLA)-DRB1 and essential hypertension (EH) in the Hans living in Yunnan of China. Methods: The alleles of HLA-DRB1 were typed by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in samples from 83 patients with essential hypertension and 91 healthy controls. All of the subjects, their grandparents and grand-grandparents are Hans living in Yunnan of China. Results: The frequency of DRB1 * 1501/2 in the EH patients (0.219) was significantly higher than that in the controls (0.060), ξ2=18.331, P<0.01. Relative risk (RR) was 4.46, and etiologic factor (EF) was 0.34. The frequency of DRB1 * 0901 significantly decreased in the group of patients with EH in comparison to the controls (0.081 versus 0.192), ξ2=8.704, P<0.05. RR was 0.41 and prevention factor (PF) was 0.19. Conclusion: HLA-DRB1 * 1501/2 is associated with the susceptiblity to essential hypertension in the Yunnan Hans of China. DRB1 * 0901 may protect one from the disease.

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第一作者机构： [1]昆明市第一人民医院昆明市临床疾病分子生物学重点实验室

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