详情页 - 云南省第一人民医院机构库

当前位置：首页 > 详情页

Five new flavonoids and their pharmacological activities from Iris tenuifolia Pall

35| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People’s Republic of China [2]School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People’s Republic of China [3]Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai, China [4]Department of Chemistry, School of Biomedicine, Mongolian National University of Medical Sciences, S. Zorig Street 3, Ulaanbaatar 14210, Mongolia [5]Department of Anesthesiology, The First People´s Hospital of Yunnan Province, 157 Jinbi Road, Kunming, 650034, People’s Republic of China

出处：

DOI：

ISSN：

关键词： Iris tenuifolia Pall Flavonoid Antioxidant activity Anti-α-glucosidase activity ROS

摘要：

Five new components including two new isoflavones, 5, 7, 2', 3'-tetrahydroxy-6-methoxyisoflavone (1), 5, 7, 2', 3'-tetrahydroxy-8-methoxyisoflavone (2), one flavonol 3, 5, 3', 4'-tetrahydroxy-7, 2'-dimethoxyflavonol (3), one flavanone (2S)-5, 7, 3'-trihydroxy-2'-methoxyflavanone (4), and one flavanonol (2R, 3R)-3, 5, 3', 4'-tetrahydroxy-7, 2'-dimethoxyflavanonol (5), along with nine known flavonoids (6-14) were isolated from under ground parts of Iris tenuifolia Pall. Their structures were elucidated by NMR and HRESIMS data and by comparison of CD spectra with compounds having similar structure. The separated compounds were evaluated for in vitro antioxidant activities by DPPH and ABTS. The α-glucosidase inhibitory activity of the compounds were evaluated with the pNPG method, the results indicated flavonoids were potential inhibitors of α-glucosidase. Moreover, in vitro anti-oxidative assay using flow cytometry indicated that compounds 1-5 showed strong oxidation resistance ability on C8D1A cells without affecting the cell viability.Copyright © 2024 Elsevier B.V. All rights reserved.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2024]版：

无

最新[2023]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

JCR分区：

出版当年[2023]版：

Q3 CHEMISTRY, MEDICINAL Q3 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q3 CHEMISTRY, MEDICINAL Q3 PHARMACOLOGY & PHARMACY

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.5 出版当年[2023版] 2.7 出版当年五年平均 3.4 出版前一年[2022版]

第一作者：

第一作者机构： [1]School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Da Dao, Nanjing 211198, People’s Republic of China

共同第一作者：

通讯作者：

通讯机构： [5]Department of Anesthesiology, The First People´s Hospital of Yunnan Province, 157 Jinbi Road, Kunming, 650034, People’s Republic of China [*1]Department of Anesthesiology, The First People’s Hospital of Yunnan Province, 157 Jinbi Road, Kunming 650034, People’s Republic of China

推荐引用方式(GB/T 7714)：

APA：

MLA：

Five new flavonoids and their pharmacological activities from Iris tenuifolia Pall

文献详情

相关文献