机构：[a]The National Clinical Research Center for Mental Disorders, China & Center of Depression, Beijing Institute for Brain Disorders & Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China[b]Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China[c]Division of Mood Disorders, Shenzhen Mental Health Centre, Shenzhen, Guangdong province, China深圳市康宁医院深圳医学信息中心[d]Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan province, China昆明医科大学附属第一医院[e]Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China[f]Peking University Institute of Mental Health (the sixth Hospital) & National Clinical Research Center for Mental Disorders & the key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China[g]Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi province, China[h]The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang province, China[i]The University of Notre Dame Australia / Marian Centre, Perth, Australia[j]School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia[k]Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
Little is known about the demographic and clinical differences between early-onset (EOB) and late-onset bipolar disorders (LOB) in Chinese patients. This multi-center study examined the demographic and clinical characteristics of EOB (521 years) and LOB ( > 21 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) from 7 psychiatric hospitals and general hospital psychiatric units across China was examined. Patients' demographic and clinical characteristics were collected using a standardized protocol and data collection procedure. There were 181 (34.8%) patients with EOB and 339 (65.2%) with LOB. Univariate analyses revealed that compared to the LOB group, the EOB group were more likely to be older, unemployed, have a longer illness duration, have BD-I and misdiagnosed as schizophrenia but were less likely to be misdiagnosed as major depressive disorder and receiving antidepressants. Multivariate analyses revealed that unemployment and longer duration of illness were independently associated with EOB. The clinical differences between early-onset and late-onset BD patients in China were largely consistent with those found in Western countries. Early-onset BD appear to be associated with poorer outcomes. Prospective studies examining the long-term outcomes in relation to age-at-onset are needed.
基金：
Capital City Clinical Practice and Research Funding of Beijing Municipal Science & Technology Commission [Z141107002514033]; Clinical Medicine Development Funding of Beijing Municipal Administration of Hospitals [ZYLX201403, ZYLX201607]
第一作者机构：[a]The National Clinical Research Center for Mental Disorders, China & Center of Depression, Beijing Institute for Brain Disorders & Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China[b]Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
共同第一作者：
通讯作者：
通讯机构：[a]The National Clinical Research Center for Mental Disorders, China & Center of Depression, Beijing Institute for Brain Disorders & Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China[b]Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China[*1]Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China.[*2]Faculty of Health Sciences, University of Macau, Avenida da Universidade, 3/F, Building E12 Taipa, Macau SAR, China.
推荐引用方式(GB/T 7714)：
Ling Zhang,Hai-Chen Yang,Xiu-Feng Xu,et al.Demographic and clinical differences between early- and late-onset bipolar disorders in a multicenter study in China[J].PSYCHIATRY RESEARCH.2016,246:688-691.doi:10.1016/j.psychres.2016.10.063.
APA：
Ling Zhang,Hai-Chen Yang,Xiu-Feng Xu,Yi-Ru Fang,Xin Yu...&Yu-Tao Xiang.(2016).Demographic and clinical differences between early- and late-onset bipolar disorders in a multicenter study in China.PSYCHIATRY RESEARCH,246,
MLA：
Ling Zhang,et al."Demographic and clinical differences between early- and late-onset bipolar disorders in a multicenter study in China".PSYCHIATRY RESEARCH 246.(2016):688-691
