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Gut microbiota and allergy/asthma: From pathogenesis to new therapeutic strategies

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机构: [1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [2]Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [3]Genetics and Pharmacogenomics Laboratory, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [4]Pathogen Biology Laboratory, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [5]Department of Cardiology, First People’s Hospital of Yunnan, Kunming, Yunnan 650500, China
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关键词: Gut microbiota Inflammation Allergy/asthma Probiotics/prebiotic treatment

摘要:
Asthma and atopy, classically associated with hyper-activation of the T helper 2 (Th2) arm of adaptive immunity, are among the most common chronic illnesses worldwide. Emerging evidence relates atopy and asthma to the composition and function of gut micro biota composition. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. Although still a relatively nascent field of research, evidence to date suggests that the gut microbiome may represent fertile targets for prevention or management of allergic asthma and other diseases in which adaptive immune dysfunction is a prominent feature. The oral probiotics/prebiotic represents a possible therapeutic for improving asthma and allergic disease. Especially, recent technological developments that permit identification of microbes and their products using culture-independent molecular detection techniques. In this review, we literaturely summarise the aggravation or improvement of metabolic diseases by role of gut microbiota, probiotics/prebiotic treatment. (C) 2016 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 过敏 4 区 免疫学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 过敏 4 区 免疫学
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出版当年[2016]版:
Q4 IMMUNOLOGY Q4 ALLERGY
最新[2023]版:
Q3 ALLERGY Q3 IMMUNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者:
第一作者机构: [1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [2]Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [3]Genetics and Pharmacogenomics Laboratory, Kunming University of Science and Technology, Kunming, Yunnan 650500, China
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通讯机构: [1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [2]Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650500, China [3]Genetics and Pharmacogenomics Laboratory, Kunming University of Science and Technology, Kunming, Yunnan 650500, China
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