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Increased Expression of Thioredoxin-1 Binding Protein-2 in Placentas in Preeclampsia

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收录情况： ◇ SCIE

作者：
Dong, Xudong[1,2,3] * ; Cai, Yanxue[1,2,3] ; Li, Ye[1,2,3] ; Jiang, Jiang[1,2,3] ; Wu, Yinping[1,2,3] ; Lv, Tao[1,2,3] ; Feng, Yuemei[1,2,3] ; Bai, Jie[2,3] ;
机构： [1]Kunming Univ Sci & Technol, Fac Environm Sci & Engn, Kunming, Peoples R China [2]Kunming Univ Sci & Technol, Sch Med, 727 South Jingming Rd, Kunming 650500, Peoples R China [3]First People Hosp Yunnan Prov, Dept Obstet, Kunming, Peoples R China
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ISSN：

关键词： inflammation oxidative stress placenta pre-eclampsia thioredoxin thioredoxin-1 thioredoxin-binding protein-2 human vitamin D3 up-regulated protein 1

摘要：
OBJECTIVE: To examine the expressions of thioredoxin-1 (TRX-1) and thioredoxin-1 binding protein-2 (TBP-2) in placentas affected by preeclampsia. STUDY DESIGN: We examined the mRNA levels of TRX-1, TBP-2, cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha) in preeclamptic (n=20) and normal placentas (n=18) by quantitative reverse transcriptase-polymerase chain reaction. RESULTS: We found the mRNA level of TRX-1 was significantly decreased (p<0.005), while the mRNA levels of TBP-2, COX-2, and TNF-alpha were significantly increased in the placentas in preeclampsia when compared to the normal group (p<0.005). CONCLUSION: These data suggest that TBP-2 may play roles in the pathophysiology of preeclampsia, probably by contributing to oxidative stress and inflammation. Thus, TBP-2 may be a potential therapeutic target for preeclampsia.

基金：
Candidates of Young and Middle Aged Academic Leaders of Yunnan Province [2006PY01-07, 2008PY045]
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 4 区 医学
小类 | 4 区 妇产科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 妇产科学
JCR分区：
出版当年[2016]版：
Q4 OBSTETRICS & GYNECOLOGY
最新[2023]版：
无

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Kunming Univ Sci & Technol, Fac Environm Sci & Engn, Kunming, Peoples R China [2]Kunming Univ Sci & Technol, Sch Med, 727 South Jingming Rd, Kunming 650500, Peoples R China [3]First People Hosp Yunnan Prov, Dept Obstet, Kunming, Peoples R China
推荐引用方式(GB/T 7714)：
Dong Xudong,Cai Yanxue,Li Ye,et al.Increased Expression of Thioredoxin-1 Binding Protein-2 in Placentas in Preeclampsia[J].JOURNAL OF REPRODUCTIVE MEDICINE.2017,62(1-2):21-25.
APA：
Dong, Xudong,Cai, Yanxue,Li, Ye,Jiang, Jiang,Wu, Yinping...&Bai, Jie.(2017).Increased Expression of Thioredoxin-1 Binding Protein-2 in Placentas in Preeclampsia.JOURNAL OF REPRODUCTIVE MEDICINE,62,(1-2)
MLA：
Dong, Xudong,et al."Increased Expression of Thioredoxin-1 Binding Protein-2 in Placentas in Preeclampsia".JOURNAL OF REPRODUCTIVE MEDICINE 62..1-2(2017):21-25

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