机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming 650500[2]Department of Cadre Health Protection, The First People's Hospital of Yunnan Province, Kunming 650032, P.R. China云南省第一人民医院
The acute or chronic administration of opioid drugs may induce oxidative damage and cellular apoptosis in the liver and kidney, and hence result in hepatic and renal damage. Thioredoxin-1 (Trx-1) and heat shock protein 70 (Hsp70) are emerging as important modulators of cellular functions. They have been shown to be involved in cellular protective mechanisms against a variety of toxic stressors. The present study was designed to investigate the effects of geranylgeranylacetone (GGA), a pharmacological inducer of Trx-1 and Hsp70, on morphine-induced hepatic and renal damage. Morphine induced apoptosis in the liver and kidney through the mitochondria-mediated apoptosis pathway, but not the endoplasmic reticulum-mediated pathway. The activation of caspases-9 and -3 was attenuated by pre-treatment with GGA. In addition, the morphine-induced increase of malondialdehyde (MDA) levels was suppressed by GGA. Furthermore, GGA enhanced morphine-induced expression of Trx-1 and Hsp70 in the liver and kidney. The findings of this study suggest that GGA may be a safe and novel therapeutic agent for morphine-induced hepatic and renal damage.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81160162, U1202227]; Candidates of the Young and Middle Aged Academic Leaders of Yunnan Province [2006PY01-07]; Application Basic Research Fund of the Yunnan Province [2009ZC165M]; foundation of Excellent Doctor Degree Dissertation of the Kunming University of Science and Technology; Key Laboratory of Medical Neurobiology, Kunming University of Science and Technology, China
第一作者机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming 650500
通讯作者：
通讯机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming 650500[*1]Kunming University of Science and Technology, Kunming 650500, P.R. China
推荐引用方式(GB/T 7714)：
Luo Fu-Cheng,Zhao Lu,Deng Juan,et al.Geranylgeranylacetone protects against morphine-induced hepatic and renal damage in mice[J].MOLECULAR MEDICINE REPORTS.2013,7(2):694-700.doi:10.3892/mmr.2012.1217.
APA：
Luo, Fu-Cheng,Zhao, Lu,Deng, Juan,Liang, Min,Zeng, Xian-Si...&Bai, Jie.(2013).Geranylgeranylacetone protects against morphine-induced hepatic and renal damage in mice.MOLECULAR MEDICINE REPORTS,7,(2)
MLA：
Luo, Fu-Cheng,et al."Geranylgeranylacetone protects against morphine-induced hepatic and renal damage in mice".MOLECULAR MEDICINE REPORTS 7..2(2013):694-700
